Pesquisa | Secretaria de Estado da Saúde

1.

Hallmarks of aging: An expanding universe.

López-Otín, Carlos; Blasco, Maria A; Partridge, Linda; Serrano, Manuel; Kroemer, Guido.

Cell ; 186(2): 243-278, 2023 01 19.

Artigo Inglês | MEDLINE | ID: mdl-36599349

2.

Hallmarks of Health.

López-Otín, Carlos; Kroemer, Guido.

Cell ; 184(1): 33-63, 2021 01 07.

Artigo Inglês | MEDLINE | ID: mdl-33340459

3.

Carbotoxicity-Noxious Effects of Carbohydrates.

Kroemer, Guido; López-Otín, Carlos; Madeo, Frank; de Cabo, Rafael.

Cell ; 175(3): 605-614, 2018 10 18.

Artigo Inglês | MEDLINE | ID: mdl-30340032

4.

Hallmarks of health.

López-Otín, Carlos; Kroemer, Guido.

Cell ; 184(7): 1929-1939, 2021 Apr 01.

Artigo Inglês | MEDLINE | ID: mdl-33798440

5.

Metabolic Control of Longevity.

López-Otín, Carlos; Galluzzi, Lorenzo; Freije, José M P; Madeo, Frank; Kroemer, Guido.

Cell ; 166(4): 802-821, 2016 Aug 11.

Artigo Inglês | MEDLINE | ID: mdl-27518560

6.

Progeria: a paradigm for translational medicine.

Gordon, Leslie B; Rothman, Frank G; López-Otín, Carlos; Misteli, Tom.

Cell ; 156(3): 400-7, 2014 Jan 30.

Artigo Inglês | MEDLINE | ID: mdl-24485450

7.

The hallmarks of aging.

López-Otín, Carlos; Blasco, Maria A; Partridge, Linda; Serrano, Manuel; Kroemer, Guido.

Cell ; 153(6): 1194-217, 2013 Jun 06.

Artigo Inglês | MEDLINE | ID: mdl-23746838

8.

Immunosuppression by Mutated Calreticulin Released from Malignant Cells.

Liu, Peng; Zhao, Liwei; Loos, Friedemann; Marty, Caroline; Xie, Wei; Martins, Isabelle; Lachkar, Sylvie; Qu, Bo; Waeckel-Énée, Emmanuelle; Plo, Isabelle; Vainchenker, William; Perez, Franck; Rodriguez, David; López-Otin, Carlos; van Endert, Peter; Zitvogel, Laurence; Kepp, Oliver; Kroemer, Guido.

Mol Cell ; 77(4): 748-760.e9, 2020 02 20.

Artigo Inglês | MEDLINE | ID: mdl-31785928

9.

New roles for mitochondrial proteases in health, ageing and disease.

Quirós, Pedro M; Langer, Thomas; López-Otín, Carlos.

Nat Rev Mol Cell Biol ; 16(6): 345-59, 2015 Jun.

Artigo Inglês | MEDLINE | ID: mdl-25970558

10.

Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.

Ugalde, Alejandro P; Bretones, Gabriel; Rodríguez, David; Quesada, Víctor; Llorente, Francisco; Fernández-Delgado, Raúl; Jiménez-Clavero, Miguel Ángel; Vázquez, Jesús; Calvo, Enrique; Tamargo-Gómez, Isaac; Mariño, Guillermo; Roiz-Valle, David; Maeso, Daniel; Araujo-Voces, Miguel; Español, Yaiza; Barceló, Carles; Freije, José Mp; López-Soto, Alejandro; López-Otín, Carlos.

EMBO J ; 41(21): e110727, 2022 11 02.

Artigo Inglês | MEDLINE | ID: mdl-36124427

11.

Decelerating ageing and biological clocks by autophagy.

Lopez-Otín, Carlos; Kroemer, Guido.

Nat Rev Mol Cell Biol ; 20(7): 385-386, 2019 07.

Artigo Inglês | MEDLINE | ID: mdl-31164727

12.

Autophagy in major human diseases.

Klionsky, Daniel J; Petroni, Giulia; Amaravadi, Ravi K; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cadwell, Ken; Cecconi, Francesco; Choi, Augustine M K; Choi, Mary E; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Deretic, Vojo; Dikic, Ivan; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; Gewirtz, David A; Green, Douglas R; Hansen, Malene; Jäättelä, Marja; Johansen, Terje; Juhász, Gábor; Karantza, Vassiliki; Kraft, Claudine; Kroemer, Guido; Ktistakis, Nicholas T; Kumar, Sharad; Lopez-Otin, Carlos; Macleod, Kay F; Madeo, Frank; Martinez, Jennifer; Meléndez, Alicia; Mizushima, Noboru; Münz, Christian; Penninger, Josef M; Perera, Rushika M; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C; Ryan, Kevin M; Sadoshima, Junichi; Santambrogio, Laura; Scorrano, Luca; Simon, Hans-Uwe; Simon, Anna Katharina; Simonsen, Anne.

EMBO J ; 40(19): e108863, 2021 10 01.

Artigo Inglês | MEDLINE | ID: mdl-34459017

13.

The U1 spliceosomal RNA is recurrently mutated in multiple cancers.

Shuai, Shimin; Suzuki, Hiromichi; Diaz-Navarro, Ander; Nadeu, Ferran; Kumar, Sachin A; Gutierrez-Fernandez, Ana; Delgado, Julio; Pinyol, Magda; López-Otín, Carlos; Puente, Xose S; Taylor, Michael D; Campo, Elías; Stein, Lincoln D.

Nature ; 574(7780): 712-716, 2019 10.

Artigo Inglês | MEDLINE | ID: mdl-31597163

14.

Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation.

Pascual-Torner, Maria; Carrero, Dido; Pérez-Silva, José G; Álvarez-Puente, Diana; Roiz-Valle, David; Bretones, Gabriel; Rodríguez, David; Maeso, Daniel; Mateo-González, Elena; Español, Yaiza; Mariño, Guillermo; Acuña, José Luis; Quesada, Víctor; López-Otín, Carlos.

Proc Natl Acad Sci U S A ; 119(36): e2118763119, 2022 09 06.

Artigo Inglês | MEDLINE | ID: mdl-36037356

15.

Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.

Murata, Daisuke; Yamada, Tatsuya; Tokuyama, Takeshi; Arai, Kenta; Quirós, Pedro M; López-Otín, Carlos; Iijima, Miho; Sesaki, Hiromi.

EMBO J ; 39(24): e105074, 2020 12 15.

Artigo Inglês | MEDLINE | ID: mdl-33200421

16.

Correction: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection.

Kuang, Ersheng; Okumura, Cheryl Y M; Sheffy-Levin, Sharon; Varsano, Tal; Shu, Vincent Chih-Wen; Qi, Jianfei; Niesman, Ingrid R; Yang, Huei-Jiun; López-Otín, Carlos; Yang, Wei Yuan; Reed, John C; Broday, Limor; Nizet, Victor; Ronai, Ze'ev A.

PLoS Genet ; 16(5): e1008795, 2020 05.

Artigo Inglês | MEDLINE | ID: mdl-32392217

17.

Regulation of autophagy by cytosolic acetyl-coenzyme A.

Mariño, Guillermo; Pietrocola, Federico; Eisenberg, Tobias; Kong, Yongli; Malik, Shoaib Ahmad; Andryushkova, Aleksandra; Schroeder, Sabrina; Pendl, Tobias; Harger, Alexandra; Niso-Santano, Mireia; Zamzami, Naoufal; Scoazec, Marie; Durand, Silvère; Enot, David P; Fernández, Álvaro F; Martins, Isabelle; Kepp, Oliver; Senovilla, Laura; Bauvy, Chantal; Morselli, Eugenia; Vacchelli, Erika; Bennetzen, Martin; Magnes, Christoph; Sinner, Frank; Pieber, Thomas; López-Otín, Carlos; Maiuri, Maria Chiara; Codogno, Patrice; Andersen, Jens S; Hill, Joseph A; Madeo, Frank; Kroemer, Guido.

Mol Cell ; 53(5): 710-25, 2014 Mar 06.

Artigo Inglês | MEDLINE | ID: mdl-24560926

18.

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.

Llobet-Navas, David; Rodríguez-Barrueco, Ruth; Castro, Verónica; Ugalde, Alejandro P; Sumazin, Pavel; Jacob-Sendler, Damian; Demircan, Berna; Castillo-Martín, Mireia; Putcha, Preeti; Marshall, Netonia; Villagrasa, Patricia; Chan, Joseph; Sanchez-Garcia, Félix; Pe'er, Dana; Rabadán, Raul; Iavarone, Antonio; Cordón-Cardó, Carlos; Califano, Andrea; López-Otín, Carlos; Ezhkova, Elena; Silva, Jose M.

Genes Dev ; 28(7): 765-82, 2014 Apr 01.

Artigo Inglês | MEDLINE | ID: mdl-24636986

19.

Molecular definitions of autophagy and related processes.

Galluzzi, Lorenzo; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cecconi, Francesco; Choi, Augustine M; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Debnath, Jayanta; Deretic, Vojo; Dikic, Ivan; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; Fulda, Simone; Gewirtz, David A; Green, Douglas R; Hansen, Malene; Harper, J Wade; Jäättelä, Marja; Johansen, Terje; Juhasz, Gabor; Kimmelman, Alec C; Kraft, Claudine; Ktistakis, Nicholas T; Kumar, Sharad; Levine, Beth; Lopez-Otin, Carlos; Madeo, Frank; Martens, Sascha; Martinez, Jennifer; Melendez, Alicia; Mizushima, Noboru; Münz, Christian; Murphy, Leon O; Penninger, Josef M; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C; Ryan, Kevin M; Santambrogio, Laura; Scorrano, Luca; Simon, Anna Katharina; Simon, Hans-Uwe; Simonsen, Anne; Tavernarakis, Nektarios; Tooze, Sharon A; Yoshimori, Tamotsu.

EMBO J ; 36(13): 1811-1836, 2017 07 03.

Artigo Inglês | MEDLINE | ID: mdl-28596378

20.

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1^- mantle cell lymphoma.

Martín-Garcia, David; Navarro, Alba; Valdés-Mas, Rafael; Clot, Guillem; Gutiérrez-Abril, Jesús; Prieto, Miriam; Ribera-Cortada, Inmaculada; Woroniecka, Renata; Rymkiewicz, Grzegorz; Bens, Susanne; de Leval, Laurence; Rosenwald, Andreas; Ferry, Judith A; Hsi, Eric D; Fu, Kai; Delabie, Jan; Weisenburger, Dennis; de Jong, Daphne; Climent, Fina; O'Connor, Sheila J; Swerdlow, Steven H; Torrents, David; Beltran, Sergi; Espinet, Blanca; González-Farré, Blanca; Veloza, Luis; Costa, Dolors; Matutes, Estella; Siebert, Reiner; Ott, German; Quintanilla-Martinez, Leticia; Jaffe, Elaine S; López-Otín, Carlos; Salaverria, Itziar; Puente, Xose S; Campo, Elias; Beà, Sílvia.

Blood ; 133(9): 940-951, 2019 02 28.

Artigo Inglês | MEDLINE | ID: mdl-30538135

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